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ACUTE KIDNEY failure is an abrupt cessation of kidney function, with lifethreatening consequences in children worldwide. Given the fact that acute kidney failure is sometimes associated with significant multiple organ system failure (MOSF) and constitutes an important population admitted to pediatric intensive care units (ICUs), it seems logical that the various risk factors of this catastrophic event are issues of great importance in terms of tangible and intangible costs to the wellbeing of patients and their families. We share a 20-year experience at a single center with care provided by the same attendings in critical care, nephrology, and neonatology. This study will analyze the underlying diseases leading to acute kidney failure, the outcome of MOSFs, and other variables associated with mortality in the first decade compared with the second decade. Recently, hypoalbuminemia has been shown to be a singular predictor of nutrition failure and presence of systemic disease in children receiving chronic renal replacement therapy. We will examine whether it is also a co-mortality risk factor in acute kidney failure. This study has particular relevance in the light of advancing technology, including the increase of extracorporeal membrane oxygenation in neonates, and the widespread and earlier use of acute renal replacement therapy.

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ACUTE KIDNEY failure is an abrupt cessation of kidney function , with lifethreatening consequences in children worldwide . Given the fact that acute kidney failure is sometimes associated with significant multiple organ system failure (MOSF) and constitutes an important population admitted to pediatric intensive care units (ICUs) , it seems logical that the various risk factors of this catastrophic event are issues of great importance in terms of tangible and intangible costs to the wellbeing of patients and their families . We share a 20-year experience at a single center with care provided by the same attendings in critical care , nephrology , and neonatology . This study will analyze the underlying diseases leading to acute kidney failure , the outcome of MOSFs , and other variables associated with mortality in the first decade compared with the second decade . Recently , hypoalbuminemia has been shown to be a singular predictor of nutrition failure and presence of systemic disease in children receiving chronic renal replacement therapy . We will examine whether it is also a co-mortality risk factor in acute kidney failure . This study has particular relevance in the light of advancing technology , including the increase of extracorporeal membrane oxygenation in neonates , and the widespread and earlier use of acute renal replacement therapy .

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ACUTE KIDNEY failure is an abrupt cessation of kidney function, with lifethreatening consequences in children worldwide. Given the fact that acute kidney failure is sometimes associated with significant multiple organ system failure (MOSF) and constitutes an important population admitted to pediatric intensive care units (ICUs), it seems logical that the various risk factors of this catastrophic event are issues of great importance in terms of tangible and intangible costs to the wellbeing of patients and their families. We share a 20-year experience at a single center with care provided by the same attendings in critical care, nephrology, and neonatology. This study will analyze the underlying diseases leading to acute kidney failure, the outcome of MOSFs, and other variables associated with mortality in the first decade compared with the second decade. Recently, hypoalbuminemia has been shown to be a singular predictor of nutrition failure and presence of systemic disease in children receiving chronic renal replacement therapy. We will examine whether it is also a co-mortality risk factor in acute kidney failure. This study has particular relevance in the light of advancing technology, including the increase of extracorporeal membrane oxygenation in neonates, and the widespread and earlier use of acute renal replacement therapy.

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epiCRealism

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May 14, 2024

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