Chronic stress is、It has emerged as an important factor influencing mitochondria

Chronic stress is、It has emerged as an important factor influencing mitochondrial function.、It has far-reaching effects on both physical and mental health.。Research、When exposed to stress for a long period of time、Transcriptional changes、Impaired energy production、Increased oxidative stress、Changes in mitochondrial dynamics, etc.、It has been shown that it can lead to mitochondrial dysfunction through a variety of mechanisms。Chronic stress is、Triggers several mechanisms that impair mitochondrial function。 • In the prefrontal cortex of stress-vulnerable subjects、酸化リン酸化に関与するMitochondrial DNAにコードされた遺伝子の発現が上昇する • 電子伝達系の効率が低下し、• ATP production decreases • Reactive oxygen species production increaseitochondrial DNA、protein、Damages lipids • Inhibits the processes of mitochondrial fusion and fission、Fragmentation occurs. Changes in mitochondrial morphology and ultrastructure occur. These dysfunctions create a vicious cycle.、Mitochondrial dysfunction exacerbates stress response and cell damage。The complex interplay between stress signaling and mitochondrial rebalancing、may be an important factor in the pathophysiology of stress-related disorders。

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