Pyruvic acid (which has three carbon atoms) generated in the glycolysis stage le

Pyruvic acid (which has three carbon atoms) generated in the glycolysis stage leaves the cytoplasm and crosses the outer mitochondrial membrane passively due to the high permeability of the same. Pyruvic acid ingresa a la matriz mitocondrial mediante un mecanismo de simporte con protones que le permite atravesar la membrana interna de la mitocondria. Inside the mitochondrial matrix, pyruvic acid undergoes oxidative decarboxylation in which the complex of three enzymes that form pyruvate dehydrogenase is involved. This enzyme complex has several cofactors, among them coenzyme A and is responsible for catalyzing the conversion of pyruvic acid to acetyl-CoA. During the process, pyruvic acid is modified, which loses a carbon atom and generates an acetyl, Acetyl-CoA (which has two carbon atoms). The released carbon is detached as a carbon dioxide molecule (CO2) and a NAD molecule is reduced+ generating NADH and H+. When this stage concludes, Acetyl-CoA ingresa al ciclo de Krebs.
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Pyruvic acid (which has three carbon atoms) generated in the glycolysis stage leaves the cytoplasm and crosses the outer mitochondrial membrane passively due to the high permeability of the same
.
Pyruvic acid ingresa a la matriz mitocondrial mediante un mecanismo de simporte con protones que le permite atravesar la membrana interna de la mitocondria
.
Inside the mitochondrial matrix
,
pyruvic acid undergoes oxidative decarboxylation in which the complex of three enzymes that form pyruvate dehydrogenase is involved
.
This enzyme complex has several cofactors
,
among them coenzyme A and is responsible for catalyzing the conversion of pyruvic acid to acetyl-CoA
.
During the process
,
pyruvic acid is modified
,
which loses a carbon atom and generates an acetyl
,
Acetyl-CoA (which has two carbon atoms)
.
The released carbon is detached as a carbon dioxide molecule (CO2) and a NAD molecule is reduced+ generating NADH and H+
.
When this stage concludes
,
Acetyl-CoA ingresa al ciclo de Krebs
.
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