|the "Genetic alterations", such as chromosomal alterations and specific genetic

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|the "Genetic alterations"
,
such as chromosomal alterations and specific genetic mutations
,
or how the presence of an additional chromosome as in Down syndrome or when there is a substitution of a single base pair that determines an amino acid situation as occurs in the case of sickle cell disease
,
which can give rise to clinical phenotypes in the form of congenital malformations or anemias
,
genetic defects
,
These genetic alterations are the cause of cellular damage
.
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