Create an image capable of explaining the physiopathological process of fever de

Create an image capable of explaining the physiopathological process of fever described from the following text: The elevation of body temperature observed with fever, and not in hyperthermia, is one of the clinical manifestations of a complex organic reaction to generally external aggressions. Agents capable of triggering fever are called exogenous pyrogens and can be classified as infectious (viruses, fungi, bacteria, and toxins) and non-infectious (antigen-antibody complexes and antigens resulting from cell destruction, such as that which occurs in hematoma reabsorption, tumor necrosis, tissue healing, etc.). When exogenous pyrogens come into contact with tissue macrophages, they induce the production of endogenous pyrogens represented mainly by interleukins (IL) 1 and IL-6 and Tumor Necrosis Factor Alpha (TNF-A), among others, which enter the bloodstream and head to the CNS (Central Nervous System) where they activate the thermoregulatory center located in the preoptic region of the hypothalamus to produce prostaglandin E2 (PgE2), the element responsible for raising the thermoregulation point. The elevation of body temperature triggered by endogenous pyrogens is modulated by the release of hormones. These, acting as endogenous antipyretics, prevent the loss of control of body temperature that could reach very high levels. This, in turn, would result in alterations in enzymatic function, inhibiting or blocking its activity. Glucocorticoids and antidiuretic hormone, as well as TNF-A, play this modulating role in response to the thermoregulatory center stimulus."

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